Leyton Orient claimed all three points from their longest round-trip of the League One season to Carlisle.
Ruel Sotiriou's first-half goal proved enough at Brunton Park, to ensure a happy return to east London for Richie Wellens' side.
Ethan Galbraith came into the starting line-up in the only change from last weekend's home win over Reading.
And Dan Happe had a header flicked over the bar by Tomas Holy on eight minutes, with O's inches away moments later as El Mizouni fired against the crossbar and Sotiriou saw his follow-up saved by Holy.
Galbraith's inviting cross evaded everyone in the box on 20 minutes, but O's opened the scoring soon after through Sotiriou, who ran onto a superb through ball from Joe Pigott and rounded Holy to slot home.
Pigott, El Mizouni and Sotiriou combined on a counter-attack later in the half, but a covering Carlisle defender did well to thwart them and put the ball out of play.
Jordan Brown was booked for a trip on Jon Mellish seven minutes before the break, with a stretching Pigott unable to get a header from Rob Hunt's cross on target in stoppage time.
Joe Garner headed a good chance from Fin Back's cross over at the start of the second half, with Sotiriou making way for Aaron Drinan in the first change of the day.
El Mizouni volleyed wide from a Pigott cross on 63 minutes, but Ed Turns was booked for a foul on Alfie McCalmont with a quarter of an hour remaining.
Turns made way for Tom James moments later, with Galbraith stinging the palms of Holy after a good O's move on 77 minutes.
Shaq Forde and Jordan Graham were sent on for Pigott and Hunt for the last nine minutes, with Sol Brynn pushing a Terry Ablade effort onto the outside of a post as the hosts pushed for a late equaliser.
El Mizouni was booked in the third minute of injury time for a foul on Ablade, but O's held on for three points.
Carlisle: Holy, Back (Edmondson 81), Armer, Moxon, Lavelle, Gibson (Ablade 71), Guy, McCalmont, Garner, Mellish, Maguire (Plange 70).
Unused subs: Andresson, Whelan, Robinson, Barclay.
Leyton Orient: Brynn, Turns (James 76), Happe, Brown, Pigott (Forde 81), Sotiriou (Drinan 58), Archibald, Cooper, El Mizouni, Galbraith, Hunt (Graham 81).
Unused subs: Howes, Sweeney, Moncur.
Attendance: 8,335 (including 424 Orient fans).
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